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90, Akt/mammalian target of rapamycin pathway, Mitogen-activated protein kinase pathway, PhosphorylationBackground Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [1]. Radiationinduced tumor genesis has also been identified. Heat shock proteins (HSPs) are chape
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90, Akt/mammalian target of rapamycin pathway, Mitogen-activated protein kinase pathway, PhosphorylationBackground Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [1]. Radiationinduced tumor genesis has also been identified. Heat shock proteins (HSPs) are chape
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90, Akt/mammalian target of rapamycin pathway, Mitogen-activated protein kinase pathway, PhosphorylationBackground Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [1]. Radiationinduced tumor genesis has also been identified. Heat shock proteins (HSPs) are chape
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Available at the end of the articlemember of the HSP family, refolds certain denatured proteins under stress conditions and activates these proteins, which are called "client proteins" [3]. The proteins include the growth-stimulating proteins and kinases that support malignant transformation [4]. One of the important client proteins is Akt [3], a serine/threonine kinase activated by phosphoinositi
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Owever, there were other studies indicating a better clinical outcome in ALDH1(+) cancer patients, using different antibodies. Our previous study, using rabbit polyclonal antibody against human ALDH1A1 (ab63026, Abcam, Cambridge, UK) has proved that ALDH1 expression in vulvar squamous cell carcinomas predicted a significantly better survival than the ALDH1 negative cases [28]. Similarly, Hessman a
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Owever, there were other studies indicating a better clinical outcome in ALDH1(+) cancer patients, using different antibodies. Our previous study, using rabbit polyclonal antibody against human ALDH1A1 (ab63026, Abcam, Cambridge, UK) has proved that ALDH1 expression in vulvar squamous cell carcinomas predicted a significantly better survival than the ALDH1 negative cases [28]. Similarly, Hessman a
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Ess This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The
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B anthracis."1 In other words, as I said in my editorial, currently no field evidence exists of AVA's effectiveness against inhalation anthrax in humans. In my view no amount of political window dressing can change this fact. Winkenwerder and Grabenstein believe that laboratory evidence from animals and humans using surrogate outcomes such as antibody responses coupled with "reasonable assumptions