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Ess This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The
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Ess This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The
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90, Akt/mammalian target of rapamycin pathway, Mitogen-activated protein kinase pathway, PhosphorylationBackground Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [1]. Radiationinduced tumor genesis has also been identified. Heat shock proteins (HSPs) are chape
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90, Akt/mammalian target of rapamycin pathway, Mitogen-activated protein kinase pathway, PhosphorylationBackground Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [1]. Radiationinduced tumor genesis has also been identified. Heat shock proteins (HSPs) are chape
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Available at the end of the articlemember of the HSP family, refolds certain denatured proteins under stress conditions and activates these proteins, which are called "client proteins" [3]. The proteins include the growth-stimulating proteins and kinases that support malignant transformation [4]. One of the important client proteins is Akt [3], a serine/threonine kinase activated by phosphoinositi
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A badly reported 1950s trial of a vaccine similar to adsorbed anthrax vaccine (AVA). This vaccine was probably effective against cutaneous anthrax but the researchers specifically concluded that no such claims could be made regarding inhalation anthrax. The Institute of Medicine report cited by Winkenwerder and Grabenstein concludes that such evidence exists as follows: "Finding: The committee fin
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90, Akt/mammalian target of rapamycin pathway, Mitogen-activated protein kinase pathway, PhosphorylationBackground Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [1]. Radiationinduced tumor genesis has also been identified. Heat shock proteins (HSPs) are chape
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90, Akt/mammalian target of rapamycin pathway, Mitogen-activated protein kinase pathway, PhosphorylationBackground Undifferentiated pleomorphic sarcoma (UPS) showing no identifiable line of differentiation is a heterogeneous tumor group as defined by the World Health Organization (WHO) classification [1]. Radiationinduced tumor genesis has also been identified. Heat shock proteins (HSPs) are chape