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Hail1river

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An carcinoma, but the expression levels had no associations with the clinical parameters, and it is not associated with survival probabilities, which was in accordance with the findings from Woodward et al. [43] and Ohi et al. [44]. The current study has several limitations. First of all, although Allred scoring system combines the percentage and intensity of positive cells, as a manual scoring sy
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An carcinoma, but the expression levels had no associations with the clinical parameters, and it is not associated with survival probabilities, which was in accordance with the findings from Woodward et al. [43] and Ohi et al. [44]. The current study has several limitations. First of all, although Allred scoring system combines the percentage and intensity of positive cells, as a manual scoring sy
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Owever, there were other studies indicating a better clinical outcome in ALDH1(+) cancer patients, using different antibodies. Our previous study, using rabbit polyclonal antibody against human ALDH1A1 (ab63026, Abcam, Cambridge, UK) has proved that ALDH1 expression in vulvar squamous cell carcinomas predicted a significantly better survival than the ALDH1 negative cases [28]. Similarly, Hessman a
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Expression in the tumor microenvironment is rather different in the above findings. Resetkova et al. hold the opinion that high expression of ALDH1 in breast cancer stromal cells had a best disease free survival and a trend of better overall survival [42], De Brot et al. confirmed that ALDH1 frequent expression in tumor-associated stromal cells of triple negative breast cancer predicted a better o
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Sion and Negative groups (p < 0.05, Kaplan-Meier). b High expression level of ALDH1 in tumor cells in ovarian carcinomas was significantly associated with high PFS probabilities (p < 0.05, Kaplan-Meier). c The expression level of ALDH1 in the stromal cells in ovarian carcinoma had no significant association with OS probabilities (p > 0.05, Kaplan-Meier). d No statistical association was found betw
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Ay, and the inhibition of ALDH1-mediated retinoid signaling impairs human fetal islet cell differentiation and survival [5]. It is also known that cancer stem cells share features of normal stem cells. Therefore, it can't be excluded in the ovarian cancer cells that ALDH1 exerts its role through the same molecular mechanism, by such contributing to the better survival in ovarian cancers, although
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Ay, and the inhibition of ALDH1-mediated retinoid signaling impairs human fetal islet cell differentiation and survival [5]. It is also known that cancer stem cells share features of normal stem cells. Therefore, it can't be excluded in the ovarian cancer cells that ALDH1 exerts its role through the same molecular mechanism, by such contributing to the better survival in ovarian cancers, although
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As remain controversial, and the present long-term follow-up retrospective study reveals that high ALDH1 expression in tumor cells portends favorable prognosis and better survivals in patients with ovarian carcinoma, but the expression of ALDH1 in stromal cells has no associations with clinical outcomes. More studies are warranted to verify the potential role of ALDH1 in ovarian carcinoma progress