With recombinant IL27 reduced the level of ETAR expression in these myeloid cells (Supplementary Figure 2). Furthermore, because ETAR levels are not detectable in kupffer cells following treatment with LPS in vivo, the isolated primary kupffer cells from these mice were re-stimulated with LPS in vitro in presence or absence of recombinant IL27 (rIL27) overnight. Indeed, rIL27 inhibited LPS to indu