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Findings into colorectal adenoma and carcinoma cell lines suggesting that PDEFindings into colorectal adenoma and carcinoma cell lines suggesting that PDE5 inhibition can directly attenuate proliferation in tumor cell lines (135). Since cyclin D1 is a target gene for the catenin/TCF-Lef complex, the proposed mechanism of cyclin D1 downregulation was shown to involve elevation of cGMP, activa