Derm forms the chorion that fuses with the allantois, an outgrowth of extraembryonic mesoderm, at around embryonic day 8 (E8) to form the placental labyrinthine layer. The spongiotrophoblast layer of the murine placenta derives from ectoplacental precursor cells and forms the middle layer of the placenta, also known as the junctional zone. The outermost placental cells are the trophoblast giant ce
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